Aryl carbamate oligomers for hydrolyzable prodrugs and...

Details Aryl carbamate oligomers for hydrolyzable prodrugs and... Aryl carbamate oligomers for hydrolyzable prodrugs and...

C - Chemistry, Metallurgy

07

C

C07C 271/12 (2006.01) A61K 47/48 (2006.01) C08G 63/685 (2006.01)

Patent

CA 2534298

The present invention provides a compound having a formula: (I) where R1 is selected from the group consisting of alkyl, -CH2(OC2H4)OCH3, and - (OC2H4)OCH3; n is 0-4; Olig is an oligomer having a formula (I) where L is a optional linker moiety selected from the group consisting of CH2O , CH2OX , OX , C(O) , C(O)X, NH , NHC(O) , XNHC(O) , NHC(O)X , C(O)NH , C(O)NHX , and (I), where X is alkyl1-6 or is not present, Y is N or O or is not present, and R3 is alkyl1-6; PAG is a linear or branched polyalkylene glycol moiety; R2 is an alkyl1-22 capping moiety if X is present or alkyl2-22 if X is not present; and q is a number from 1 to the maximum number of branches on PAG; and m is 1-5.

La présente invention concerne un composé ayant la formule (I) dans laquelle R?1¿ est sélectionné dans le groupe constitué d'alkyle, -CH¿2?(OC¿2?H4)OCH¿3?, et -(OC¿2?H¿4?)OCH¿3?; n est 0-4; Olig est un oligomères possédant la formule (I) dans laquelle L est un groupe fonctionnel de liaison sélectionné parmi CH¿2?O, CH¿2?OX, OX, C(O), C(O)X, NH, NHC(O), XNHC(O), NHC(O)X, C(O)NH, C(O)NHX et (I), où X est alkyle¿1-6? ou est absent, Y est N ou O ou est absent, et R?3¿ est alkyle¿1-6?; PAG est un groupe fonctionne de polyalkylène glycol linéaire ou ramifié, R?2¿ est un groupe fonctionnel chaperon d'alkyle¿1-22? si X est présent ou alkyle¿2-22? si X est absent; et q est un nombre entre 1 et le nombre maximal de ramifications sur PAG alors que m est 1-5.

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