Aryl derivatives

Details Aryl derivatives Aryl derivatives

C - Chemistry, Metallurgy

07

D

C07D 309/12 (2006.01) A61K 31/35 (2006.01) A61K 31/395 (2006.01) C07D 309/10 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2055530

A B S T R A C T ARYL DERIVITIVES The invention concerns an aryl derivative of the formula I, Image I wherein Ar1 is optionally substituted phenyl, naphthyl or a heterocyclic moiety, and X1 is oxy, thio, sulphinyl, sulphonyl, difluoromethylene, imino, (1-4C)alkylimino or optionally substituted (1-4C)alkylene, or X1 is a group of the formula -X4-CR2- or -CR2-X4- wherein X4 is oxy, thio, sulphinyl, sulphonyl or carbonyl and each R is hydrogen, methyl or ethyl; each of Ar2 and Ar3 is optionally substituted phenylene; X2 is oxy, thio, sulphinyl or sulphonyl; R1 is (1-4C)alkyl; and R2 and R3 together form a group of the formula -A1-X3-A2- which together with the carbon atom to which A1 and A2 are attached define a ring having 5 to 7 ring atoms, wherein each of A1 and A2 is (1-3C)alkylene and X3 is oxy, thio, sulphinyl or sulphonyl; which compounds are inhibitors of 5-lipoxygenase and are useful in the treatment of inflammatory or allergic disease.

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