C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/34 (2006.01) A61K 31/425 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/428 (2006.01) A61K 31/4439 (2006.01) A61K 31/497 (2006.01) A61K 31/56 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) C07D 277/20 (2006.01) C07D 277/82 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07J 3/00 (2006.01)
Patent
CA 2460150
The subject invention provides pharmaceutical compounds useful in the treatment of Type II diabetes. These compounds are advantageous because they are readily metabolized by the metabolic drug detoxification systems. Particularly, thiazolidinedione analogs that have been designed to include esters within the structure of the compounds are provided. This invention is also drawn to methods of treating disorders, such as diabetes, comprising the administration of therapeutically effective compositions comprising compounds that have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester-containing thiazolidinedione analogs are also taught.
L'invention concerne des composés pharmaceutiques utiles dans le traitement des diabètes de type II. Ces composés sont avantageux parce qu'ils sont facilement métabolisés par les systèmes de désintoxication de substances métaboliques. L'invention concerne en particulier des analogues de thiazolidinedione conçus pour comprendre des esters à l'intérieur de la structure de ces composés. L'invention concerne également des procédés de traitement de troubles, notamment de diabètes, comprenant l'administration de compositions thérapeutiquement efficaces comprenant des composés conçus pour être métabolisés par des hydrolases et des estérases intracellulaires ou de sérum. L'invention concerne encore des compositions pharmaceutiques d'analogues de thiazolidinedione contenant des esters.
Druzgala Pascal
Milner Peter G.
Pfister Jurg R.
Aryx Therapeutics
Mbm Intellectual Property Law Llp
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