Aryl di-substituted propenone compounds

Details Aryl di-substituted propenone compounds Aryl di-substituted propenone compounds

C - Chemistry, Metallurgy

07

C

C07C 49/213 (2006.01) A61K 31/12 (2006.01) A61P 1/00 (2006.01) A61P 5/24 (2006.01) A61P 9/00 (2006.01) A61P 17/06 (2006.01) A61P 17/10 (2006.01) A61P 17/16 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C07C 49/217 (2006.01) C07C 49/245 (2006.01) C07C 49/248 (2006.01)

Patent

CA 2743661

Compounds of formula (I): wherein R1 and R4 are OR7, R2 and R3 are H or OR7, with the proviso that when R2 is OR7 then R3 is H, and when R3 is OR7 then R2 is H; R5 and R6 are independently H, OH, or OR7 with the proviso that when R5 is OH, R6 is not OH; R7 is alkyl, aryl or arylalkyl; the drawing "(a)" represents either a single or a double bond; or pharmaceutically acceptable salt(s) or prodrug(s) thereof are disclosed. These novel compounds are useful of treatment, prophylaxis, amelioration, or defence against and / or prevention of hormonal dependent conditions, cancer, and diseases and conditions associated with oxidant stress.

La présente invention concerne des composés de formule (I): dans laquelle R1 et R4 sont OR7, R2 et R3 sont H ou OR7, à condition que lorsque R2 est OR7 alors R3 est H, et lorsque R3 est OR7 alors R2 est H; R5 et R6 sont indépendamment H, OH, ou OR7 à condition que lorsque R5 est OH, R6 nest pas OH; R7 est alkyle, aryle or arylalkyle; le symbole « » représente soit une liaison simple ou une double liaison; ou leur(s) sel(s) ou promédicament(s) pharmaceutiquement acceptable(s). Ces nouveaux composés sont utiles pour le traitement, la prophylaxie, lamélioration, ou la défense contre et/ou la prévention de conditions hormono-dépendantes, le cancer et des maladies et des conditions associées au stress oxydatif.

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