Aryl-ester phosphoramidate derivatives of nucleosides

Details Aryl-ester phosphoramidate derivatives of nucleosides Aryl-ester phosphoramidate derivatives of nucleosides

C - Chemistry, Metallurgy

07

H

C07H 19/20 (2006.01) A61K 31/7064 (2006.01) C07H 19/10 (2006.01) A61K 31/675 (2006.01) C07F 9/6512 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2215190

The invention relates to masked monophosphate nucleoside analogues, their preparation and their therapeutic use in the treatment of viral infection, including infection by HIV. In particular, the invention relates to aryl phosphoramidate 2',3'-dideoxy and 2',3'-dideoxydidehydro of nucleoside analogues and of PMEA.

L'invention concerne des analogues de nucléosides monophosphatés masqués, leur préparation et leur usage thérapeutique dans le traitement des infections virales, notamment l'infection par le VIH. L'invention concerne en particulier le 2',3'-didésoxy et le 2',3'-didésoxydidéhydro arylphosphoramidate d'analogues de nucléosides et de PMEA.

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