Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine...

Details Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine... Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine...

C - Chemistry, Metallurgy

07

D

C07D 243/10 (2006.01) A61K 31/55 (2006.01) C07D 243/04 (2006.01) C07D 245/06 (2006.01) C07D 401/02 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 405/02 (2006.01) C07D 405/04 (2006.01) C07D 409/02 (2006.01) C07D 413/06 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2104060

ABSTRACT OF THE DISCLOSURE Aryl-fused- and hetaryl-fused-2,4-diazepines of formula XXXVI, Image XXXVI wherein A is an aryl or hetaryl ring; R1 is hydrogen, alkyl, aryl or hetaryl; R2 is hydrogen, alkyl, substituted alkyl, or aryl; R3 is alkyl, aryl, aralkyl or heteroatom substituted alkyl or aralkyl; R4 is hydrogen or alkyl; R5 is hydrogen, alkyl, aryl or hetaryl; R6 is hydrogen, alkyl, alkoxy, halogen or a fused benzene ring; R9 is hydrogen, alkyl, or substituted alkyl; and R10 is hydrogen, alkyl, or substituted alkyl. The invention further relates to pharmaceutical compositions containing, and methods of treating cardiac arrhythmia with the compounds of formula XXXVI.

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