Aryl-fused and hetaryl-fused-2,4 diazepine and 2,4-diazocine...

Details Aryl-fused and hetaryl-fused-2,4 diazepine and 2,4-diazocine... Aryl-fused and hetaryl-fused-2,4 diazepine and 2,4-diazocine...

C - Chemistry, Metallurgy

07

D

C07D 243/04 (2006.01) A61K 31/135 (2006.01) A61K 31/16 (2006.01) A61K 31/55 (2006.01) C07C 211/27 (2006.01) C07C 211/29 (2006.01) C07C 211/30 (2006.01) C07C 217/08 (2006.01) C07C 217/58 (2006.01) C07C 217/84 (2006.01) C07C 233/35 (2006.01) C07C 233/36 (2006.01) C07C 233/40 (2006.01) C07C 235/34 (2006.01) C07C 311/06 (2006.01) C07D 245/06 (2006.01) C07D 295/13 (2006.01) C07D 295/15 (2006.01) C07D 333/20 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 405

Patent

CA 2050962

D.N. 2510B ABSTRACT OF THE DISCLOSURE Aryl-fused- and hetaryl-fused-2,4-diazepines of formula XXXVI, benzodiazocines of formula XXX, benzodiazepines of formula II Image Image XXXVI XXX Image II ?-aminoamides of formula III and aryldimethanamines of formula XXXVII Image Image III XXXVII D.N.2510B wherein A is an aryl or hetaryl ring; R1 is hydrogen, alkyl, aryl or hetaryl; R2 is hydrogen, alkyl, substituted alkyl, or aryl; R3 is alkyl, aryl, aralkyl or heteroatom substituted alkyl or aralkyl; R4 is hydrogen or alkyl; R5 is hydrogen, alkyl, aryl or hetaryl; R6 is hydrogen, alkyl, alkoxy, halogen or a fused benzene ring; R9 is hydrogen, alkyl, or substituted alkyl; and R10 is hydrogen, alkyl, or substituted alkyl. The invention further relates to processes for the preparation of, pharmaceutical compositions containing, and methods of treating cardiac arrhythmia with the compounds of formulas XXXVI, XXX, II, III, and XXXVII.

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