Aryl halide substituted metallic complexes, pharmaceuticals...

Details Aryl halide substituted metallic complexes, pharmaceuticals... Aryl halide substituted metallic complexes, pharmaceuticals...

C - Chemistry, Metallurgy

07

F

C07F 5/00 (2006.01) A61K 49/00 (2006.01) A61K 49/04 (2006.01) A61K 49/06 (2006.01) C07C 229/16 (2006.01) C07C 233/25 (2006.01) C07C 233/54 (2006.01) C07C 235/46 (2006.01) C07C 237/22 (2006.01) C07C 237/46 (2006.01) C07C 271/28 (2006.01) C07C 275/40 (2006.01) C07F 11/00 (2006.01) C07F 15/02 (2006.01)

Patent

CA 2177977

The invention pertains to new metallic complexes containing an ion of an element of atomic number 12, 13, 20-31, 39-42, 44-50 or 57-83 and a halogenated complexing ligand of formula (I), where R1, R2, R3, Z1, Z2, Z3, U1, U2, V1, V2 or V3 have various meanings. The invention pertains as well to pharmaceuticals containing these complexes, to their use in NMR and/or X-ray diagnostics, especially in X-ray diagnosis of the liver, and to methods for preparing the complexes and pharmaceuticals.

L'invention concerne de nouveaux complexes métalliques qui contiennent un ion d'un élément des nombres atomiques 12, 13, 20-31, 39-42, 44-50 ou 57-83 et un ligand complexant halogéné de formule (I), dans laquelle R?1¿, R?2¿, R?3¿, Z?1¿, Z?2¿, Z?3¿, U?1¿, U?2¿, V?1¿, V?2¿ ou V?3¿ ont différentes notations. L'invention concerne des substances pharmaceutiques contenant lesdits complexes, leur utilisation dans la résonance magnétique nucléaire et/ou dans le radiodiagnostic, notamment dans celui du foie, ainsi que des procédés de préparation desdits complexes et desdites substances pharmaceutiques.

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