Aryl heterocyclic cgrp receptor antagonists

Details Aryl heterocyclic cgrp receptor antagonists Aryl heterocyclic cgrp receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/20 (2006.01) A61K 31/437 (2006.01) A61P 25/06 (2006.01)

Patent

CA 2683757

Compounds of formula I: I (wherein variables A1, A2, B, m, n, J, X, R4, G1, G2, G3 and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

L'invention porte sur des composés de formule I: I (où les variables A1, A2, B, m, n, J, X, R4, G1, G2, G3 et Y sont tels que décrits présentement) qui sont des antagonistes de récepteurs du CGRP et qui sont utiles dans le traitement ou la prévention de maladies dans lesquelles le CGRP est mis en jeu, telles que la migraine. L'invention porte également sur des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et compositions dans la prévention ou le traitement de maladies dans lesquelles le CGRP est mis en jeu.

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