C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/28 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) C07D 251/14 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2714743
Certain aryl-hydroxyethylamino-pyrimidine and triazine compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). Methods of synthesizing such compounds are also disclosed.
L'invention porte sur certains composés aryl-hydroxyéthylamino-pyrimidines et triazines, qui sont utiles en tant qu'inhibiteurs d'amide d'acide gras hydrolase (FAAH). De tels composés peuvent être utilisés dans des compositions pharmaceutiques et des procédés pour le traitement d'états de maladie, de troubles et d'états à médiation par l'activité amide d'acide gras hydrolase (FAAH), tels que l'anxiété, la douleur, une inflammation, les troubles du sommeil, les troubles de l'alimentation, les troubles du métabolisme énergétique et des troubles du mouvement (par exemple, la sclérose en plaques). L'invention porte également sur des procédés de synthèse de tels composés.
Apodaca Richard
Breitenbucher J. Guy
Chambers Alison L.
Deng Xiaohu
Hawryluk Natalie A.
Janssen Pharmaceutica N.v.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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