C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) A61K 31/505 (2006.01) A61P 25/00 (2006.01) C07D 209/02 (2006.01) C07D 213/32 (2006.01) C07D 401/14 (2006.01) C07D 453/02 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2389645
Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof aryl olefinic azacyclic compounds and aryl acetylenic azacylic compounds, including pyridyl olefinic cycloalkylamines and pyridyl acetylenic cycloalkylamines. Exemplary compounds include (S)-(E)-3-(3-pyrrolidin-2-yl- prop-1-enyl)pyridine, (S)-(E)-3-(2-pyrrolidin-2-ylvinyl)pyridine, 3-(2- pyrrolidin-2-ylethenyl)pyridine, 3-(3-pyrrolidin-2-ylprop-1-enyl)pyridine, 3- (2-(2-azetidinyl)ethenyl)pyridine, 3-(3-(2-azetidinyl) prop-1-enyl)pyridine, 2- (2-(3-pyridyl)ethenyl)-1-azabicyclo[3.3.0]octane, 2-(3-(3-pyridyl)prop-2-enyl)- 1-azabicyclo[3.3.0]octane, 3-(2-(3-pyridyl)ethenyl)-2- azabicyclo[2.2.1]heptane, 3-(3-(3-pyridyl)prop-2-enyl)-2- azabicyclo[2.2.1]heptane, 2-(2-(3-pyridyl)ethenyl)-7-azabicyclo[2.2.1]heptane, 2-(3-(3-pyridyl)prop-2-enyl)-7-azabicyclo[2.2.1]heptane, 2-(2-(3- pyridyl)ethenyl)quinuclidine and 2-(3-(3-pyridyl)prop-2-enyl)quinuclidine.
La présente invention concerne le traitement de patients sensibles à/souffrant d'affections et de troubles, tels que des troubles du système nerveux central, par administration, si le patient le nécessite, de composés azacycliques oléfiniques d'aryle et de composés azacycliques acétyléniques d'aryle, notamment de cycloalkylamines oléfiniques de pyridyle et de cycloalkylamines acétyléniques de pyridyle. Des exemples de composés comprennent (S)-(E)-3-(3-pyrrolidine-2-yle-prop-1-ényle)pyridine, (S)-(E)-3-(2-pyrrolidine-2-ylvinyle)pyridine, 3-(2-pyrrolidine-2-yléthenyle)pyridine, 3-(3-pyrrolidine-2-ylprop-1-ényle)pyridine, 3-(2-(2-azétidinyle)éthényle)pyridine, 3-(3-(2-azétidinyle)prop-1-ényle)pyridine, 2-(2-(3-pyridyle)éthényle)-1-azabicyclo[3.3.0]octane, 2-(3-(3-pyridyle)prop-2-ényle)-1-azabicyclo[3.3.0]octane, 3-(2-(3-pyridyle)éthényle)-2-azabicyclo[2.2.1]heptane, 3-(3-(3-pyridyle)prop-2-ényl)-2-azabicyclo[2.2.1]heptane, 2-(2-(3-pyridyle)éthényle)-7-azabicyclo[2.2.1]heptane, 2-(3-(3-pyridyle)prop-2-ényle)-7-azabicyclo[2.2.1]heptane, 2-(2-(3-pyridyle)éthényle)quinuclidine et 2-(3-(3-pyridyle)prop-2-ényle)quinuclidine.
Bhatti Balwinder Singh
Dull Gary Maurice
Schmitt Jeffrey Daniel
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Targacept Inc.
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