C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/295, 260/559
C07C 69/76 (2006.01) C07C 29/40 (2006.01) C07C 33/20 (2006.01) C07C 37/11 (2006.01) C07C 43/23 (2006.01) C07C 45/30 (2006.01) C07C 45/44 (2006.01) C07C 47/575 (2006.01) C07C 49/84 (2006.01) C07C 59/68 (2006.01) C07C 65/24 (2006.01) C07C 229/38 (2006.01) C07D 213/30 (2006.01) C07D 213/79 (2006.01) C07D 215/14 (2006.01)
Patent
CA 1258456
ABSTRACT OF THE DISCLOSURE: Compounds of the structure: Image and pharmaceutically acceptable salts thereof, wherein R1 and R2 are independently hydrogen, alkyl, carboxy, alkanoyloxy, aroyloxy, carboxyalkyl, carbalkoxy- alkyl, carbalkoxy, alkanoyl, formyl, nitrile, amino, aminoalkyl, alkylamino, carboxamide, halo, trihalomethyl, hydroxy, aryloxy, nitro, sulfamyl, thio, alkylthio, and Rl and R2 when taken together with the carbon atoms to which they are a-ttached form a phenyl ring; Z is CH or N, X is -O-,-S-, ?NR4,-CH2Z1-, -CH=N-, -CH=CH-, -C?C-, ?C=O, -CH2Z1CH2-, Y is -CHCH2-, -CH=CH-, -CHCHR5- or -CH(C(R5)3)2- when R3 is monovalent or Y is -C-CH2- when R3 is 0; R3is O, OH, OR4, SH, SR4, NH, HNR4, H or N(R4)2; and M is an integer from 0 to 10; wherein Z1 is O, S , Image ; R4 is H, alkyl, pyranyl or aryl; and R5 is H, alkyl or fluoro. The compounds possess antiinflammatory and antiallergic activity.
442372
Chakraborty Utpal R.
Musser John H.
Mcfadden Fincham
Usv Pharmaceutical Corporation
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