C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/233, 260/326
C07D 207/34 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01)
Patent
CA 2008616
This invention relates to novel aryl- or heteroaryl-1- alkyl-pyrrole-2-carboxylic acid compounds useful in treating interleukin-1 mediated conditions. These compounds are of the formula: (See fig I) wherein (C1-C6) is a straight or branched alkyl chain consisting of from 1 to 6 carbon atoms and X is phenyl, naphthyl, or biphenyl, each optionally substituted with one, two or three substituents selected from the group consisting of C1-C4 alkyl (with the proviso that when X is unsubstituted phenyl, (C1-C6) must be other than methylene one or an ethylene bridge, and when X is unsubstituted naphthyl, (C1-C6) must be other than methylene, and with the proviso that when X is substituted phenyl and (C1-C6) is ethylene, the substituent must be other than 4-methyl); or X is furanyl, optionally substituted with a single substituent selected from the group consisting of C1-C4 alkyl (with the proviso that when X is unsubstituted furanyl, (C1-C6) must be other than methylene, or a salt thereof.
Ku George
Parker Roger A.
Aventis Pharma Inc.
Osler Hoskin & Harcourt Llp
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