C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/58 (2006.01) C07C 233/81 (2006.01) C07C 233/88 (2006.01) C07C 235/66 (2006.01) C07C 327/48 (2006.01) C07D 215/40 (2006.01) C07D 215/48 (2006.01) C07D 335/06 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2238274
Compounds of formula (I) where X is S, O, NR' where R' is H or alkyl of 1 to 6 carbons, or X is [C(R1)2]n where n is an integer between 0 and 2; 1; Y is a phenyl or naphthyl group, or heteroaryl group; W is a substituent selected from the group consisting of F, Br, Cl, I, C1-6alkyl, fluoro substituted C1-5 alkyl, NO2, N3, OH, OCH2OCH3, OC1-10alkyl, tetrazol, CN, SO2C1-6-alkyl, SO2C1-6-fluoro substituted alkyl, SO-C1-6 alkyl, CO-C1-6alkyl, COOR8, phenyl, phenyl itself substituted with a W group other than with phenyl or substituted phenyl; L is -(C-Z)-NH- or -HN-(C=Z)-; Z is O or S; A is (CH2)q where q is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, alkenyl having 2-6 carbons and 1 or 2 double bonds, alkynyl having 2-6 carbons and 1 or 2 triple bonds, and B is COOH or a pharmaceutically acceptable salt thereof, COOR8, CONR9R10, -CH2OH, CH2OR11, CH2OCOR11, CHO, CH(OR12)2, CHOR13O, -COR7, CR7(OR12)2, CR7OR13O, where R1 -R13 and o, p, m, n, r are as defined in claim 1, have retinoid-like biological activity.
Composés de formule (I) où X est S, O, NR', où R' est H ou alkyle avec 1 à 6 carbones, ou X est [C(R1)2]n où n est un entier compris entre 0 et 2; 1; Y est un groupe phényle ou naphtyle, ou un groupe hétéroaryle; W est un substituant choisi dans le groupe constitué de F, Br, Cl, I, C1-6 alkyle, C1-6 alkyle fluoro-substitué, NO2, N3, OH, OCH2OCH3, OC1-10 alkyle, tétrazole, CN, SO2C1-6-alkyle, SO2C1-6 alkyle fluoro-substitué, SO-C1-6 alkyle, CO-C1-6 alkyle, COOR8, phényle, le phényle étant substitué avec un groupe W autre que phényle ou phényle substitué; L est -(C=Z)-NH- or -HN-(C=Z)-; Z est O ou S; A est (CH2)q où q est 0-5, alkyle inférieur à chaîne ramifiée possédant 3-6 carbones, cycloalkyle possédant 3-6 carbones, alcényle possédant 2-6 carbones et 1 ou 2 doubles liaisons, alcynyle possédant 2-6 carbones et 1 ou 2 triples liaisons; et B est COOH ou un de ses sels pharmaceutiquement acceptables COOR8, CONR9R10, -CH2OH, CH2OR11, CH2OCOR11, CHO, CH(OR12)2, CHOR13O, -COR7, CR7(OR12)2, CR7OR13O, où R1 -R13 et o, p, m, n, r sont tels que définis dans la revendication 1. Ces composés ont une activité biologique de type rétinoïde.
Chandraratna Roshantha A.
Duong Tien T.
Teng Min
Allergan
Allergan Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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