Aryl or heteroaryl fused imidazole derivatives, their...

Details Aryl or heteroaryl fused imidazole derivatives, their... Aryl or heteroaryl fused imidazole derivatives, their...

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61K 31/437 (2006.01) A61P 3/10 (2006.01) A61P 19/10 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 43/00 (2006.01) C07D 413/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2369971

Amine derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, which are useful as therapeutic and/or preventive agents for diabetes, hyperlipemia, arteriosclerosis, cancers, and so on: wherein R1 is optionally substituted carbamoyl or the like; R2 is hydrogen or the like; R3 is C1-C10 alkyl or the like; W1, W2 and W3 are each independently a single bond or C1-C8 alkylene; X, Y and Q are each sulfur or the like; Z is =CH- or the like; Ar is a benzene ring or the like; and L is hydrogen or the like.

L'invention se rapporte à des dérivés amine représentés de formule générale (I) ou à un sel pharmaceutiquement acceptable de ces dérivés, qui s'avèrent utiles en tant qu'agents thérapeutiques et/ou préventifs du diabète, de l'hyperlipidémie, de l'artériosclérose, du cancer, etc. Dans la formule (I), R¿1? est carbamoyle éventuellement substitué ou analogue; R¿2? est hydrogène ou analogue; R¿3? est alkyle C¿1?-C¿10? ou analogue; W¿1?, W¿2? et W¿3? sont chacun indépendamment une liaison simple ou un alkylène C¿1?-C¿8?; X, Y et Q sont chacun soufre ou analogue; Z est =CH- ou analogue; Ar est un noyau benzène ou analogue; et L est hydrogène ou analogue.

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