Aryl-propyl-amines endowed with antifungal activity

Details Aryl-propyl-amines endowed with antifungal activity Aryl-propyl-amines endowed with antifungal activity

C - Chemistry, Metallurgy

07

D

260/245.2, 167/6

C07D 265/30 (2006.01) A01N 33/10 (2006.01) A01N 43/40 (2006.01) A01N 43/54 (2006.01) A01N 43/84 (2006.01) A01N 55/00 (2006.01) C07D 213/643 (2006.01) C07D 239/34 (2006.01) C07D 295/096 (2006.01) C07D 417/12 (2006.01) C07F 7/08 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2037361

"ARYL-PROPYL-AMINES ENDOWED WITH ANTIFUNGAL ACTIVITY" Abstract Aryl-propyl-aminic compounds endowed with antifungal activity are disclosed, which have the general formula: Image (I) wherein: R1 and R2, which may be either equal to, or different from, each other, represent H atoms, (C1-C6)-alkyl groups, Ar-B groups in which Ar is a (C8-C10)-aryl or (C8-10)-halo-aryl group and B is a (C1-C4)-alkylene or (C1-C2)-alkyl-(C1- C4)-alkylene group, -2- or, taken together with each other and together with the N atom, Ar and B represent a (03-C8)- heterocyclic group or a (C2-C7)-heterocyclic group containing a second heteroatom selected from among O and S, with said heterocyclic groups being optionally substituted with one or more (C1-C4)-alkyl groups, (C6-C10)-aryl groups, Ar-B groups as defined above, and halogens; R3 represents a (C1-C3)-alkyl group; R4 which, when m is higher than 1, may be either different from, or equal to, one another, represent halogen atoms, (C1-C3)-alkyl groups or (C1-C3)-halo-alkyl groups; m is an integer comprised within the range of from 0 to 4; R', R'', which may be either equal to, or different from, each other, represent H, (C1-C3)-alkyl group, halogen atoms; n is an integer comprised within the range of from 0 to 3; Y represents a -CH=CH2 (ethenyl) group, a (C3-C6)- cycloalkyl group, a 5- or 6-membered heterocyclic group, while said groups can be optionally substituted with one or more halogen atoms, (C1- C4)-alkyl groups, (C1-C2)-haloalkyl groups, (C1- - 3 - C3)-alkoxy groups, (C1-C3)-halo-alkoxy groups; or represents a Image group in which C, D, E, either equal to, or different from, one another, represent H atoms, (C1-C4)- alkyl groups, (C1-C4)-haloalkyl groups, (C1-C4)-alkoxy groups, (C1-C4)-halo- alkoxy groups, (C6-C10)-aryl groups, and (C6-C10)-haloaryl groups.

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