C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4985 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2721575
The present invention pertains generally to the field of therapeutic compounds for treating proliferative disorders, cancer, etc., and more specifically to certain aryl-quinolyl compounds, as described herein, which, inter alia, inhibit RAF (e.g., B-RAF) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit RAF (e.g., BRAF) activity, to inhibit receptor tyrosine ki-nase (RTK) activity, to inhibit cell proliferation, and in the treatment of diseases and disorders that are ameliorated by the inhibition of RAF, RTK, etc., proliferative disorders such as cancer (e.g., colorectal cancer, melanoma), etc.
La présente invention se rapporte de manière générale au domaine des composés thérapeutiques destinés au traitement des troubles prolifératifs, du cancer, etc., et de manière plus spécifique à certains composés aryl-quinoléyle, tels que décrits dans ce document, qui, entre autres, inhibent lactivité de RAF (par exemple, B-RAF). La présente invention concerne également des compositions pharmaceutiques renfermant de tels composés et lutilisation de tels composés et compositions, à la fois in vitro et in vivo, pour inhiber lactivité de RAF (par exemple, B-RAF), pour inhiber lactivité de récepteurs tyrosine kinase (RTK), pour inhiber la prolifération cellulaire et dans le traitement de maladies et de troubles qui sont améliorés par linhibition de RAF, RTK, etc., de troubles prolifératifs tels que le cancer (par exemple, un cancer colorectal, un mélanome), etc.
Marais Richard
Niculescu-Duvaz Dan
Niculescu-Duvaz Ion
Springer Caroline Joy
Whittaker Steven
Cancer Research Technology Limited
Institute Of Cancer Research: Royal Cancer Hospital (the)
Kirby Eades Gale Baker
LandOfFree
Aryl-quinolyl compounds and their use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aryl-quinolyl compounds and their use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aryl-quinolyl compounds and their use will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1985774