Aryl-substituted benzo[d]isothiazol-3-ylamine analogues as...

C - Chemistry – Metallurgy – 07 – D

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C07D 417/04 (2006.01) A61K 31/425 (2006.01) C07D 275/06 (2006.01)

Patent

CA 2531515

Aryl-substituted benzo[d]isothiazol-3-ylamine analogues are provided, of the Formula (I): wherein variables are as described herein. Such compounds are ligands that may be used to modulate capsaicin in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological capsaicin receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

L'invention concerne des analogues de benzo[d]isothiazol-3-ylamine à substitution aryle représentés par la formule (I) dans laquelle des variables sont décrites. Ces composés sont des ligands pouvant être utilisés pour moduler une activité specifique de récepteur in vivo ou in vitro, et sont particulièrement utiles pour traiter des états associés à une activation pathologique de récepteur chez les humains, les animaux de compagnie domestiqués et les animaux d'élevage. L'invention concerne également des compositions pharmaceutiques et des méthodes d'utilisation de ces composés pour traiter les troubles précités ainsi que des méthodes permettant d'utiliser ces ligands dans des études de localisation de récepteur.

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