C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/367.1, 260/3
C07D 307/42 (2006.01) C07C 45/63 (2006.01) C07C 45/71 (2006.01) C07C 59/68 (2006.01) C07D 307/54 (2006.01) C07D 307/58 (2006.01) C07F 9/40 (2006.01)
Patent
CA 1152087
ABSTRACT OF THE DISCLOSURE Aryl substituted furanes and pharmaceutically acceptable acid addition salts thereof according to the following formula Image (I) wherein R1 and R2 may be the same or different and are selected from hydrogen, halogen, alkyl and acylamino having 1 to 4 carbon atoms, R3 and R4 may be the same or different and are selected from hydrogen and methyl, R5 is selected from hydrogen, dimethoxyphenyl and acylamino having the following formula R6 - CONH- wherein R6 is selected from alkyl having 1 to 4 carbon -1- atoms, are disclosed which are useful as anti-hyper- tensive and .beta.-adrenolytic agents. Also, substituted furanes having the formula Image (III) wherein R7 is selected from hydrogen, benzyl, the radical Image , and the radical Image , wherein X is selected from chlorine and bromine, are disclosed which are useful in the preparation of the aryl substituted furanes, Compositions containing the aryl substituted furanes, and methods of preparation are also disclosed. -2-
349334
Beiersdorf Aktiengesellschaft
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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