Aryl substituted hydantoin compounds and their use as sodium...

Details Aryl substituted hydantoin compounds and their use as sodium... Aryl substituted hydantoin compounds and their use as sodium...

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/415 (2006.01) A61K 31/445 (2006.01) A61K 31/454 (2006.01) C07D 233/02 (2006.01) C07D 233/74 (2006.01)

Patent

CA 2492210

This invention relates to aryl substituted hydantoins of Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein n, A, A', R, R1 and R2, are defined in the specification. The invention is also directed to the use of compounds of Formula (I) for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

La présente invention concerne des hydantoïnes aryle substituées représentées par la formule (I) ou un sel de ces composés répondant aux normes pharmaceutiques, un promédicament ou un solvate de ceux-ci. Dans cette formule n, A, A', R, R1 et R2 sont tels que définis dans les spécifications. Cette invention concerne aussi l'utilisation des composés représentés par la formule (I) dans le traitement d'une dégradation neuronale suivant une ischémie focale ou globale, dans le traitement ou la prévention d'états neurodégénératifs tels que la sclérose latérale amyotrophique (SLA) et dans le traitement, la prévention ou l'amélioration de douleurs chroniques et aiguës, sous la forme d'agents antitintement, d'anticonvulsants et de neurodépresseurs antimaniaques, d'agents anesthésiques, d'anti-arythmisants et dans le traitement ou la prévention de neuropathie diabétiques.

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