C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/266
C07D 401/06 (2006.01) C07D 207/335 (2006.01) C07D 231/12 (2006.01) C07D 403/06 (2006.01) C07D 405/14 (2006.01)
Patent
CA 1279645
ABSTRACT The invention relates to new aryl-substituted (N-piperi- dinyl)methyl- and (N-piperazinyl)methylazoles having interesting pharmacological, notably antipsychotic, properties. These compounds have the formula 1 Image (1) in which the symbols have the following meanings: R is alkyl, hydroxyalkyl or alkylthio having a 1-3 C-atoms, nitro, halogen, trifluoromethyl or alkylsulphonyl having 1-3 C-atoms; n is 0 to 4; R1, R2 and R3 independently of each other are hydrogen or methyl; X is a nitrogen atom or X is a carbon atom which is substituted with a group R5, in which R5 is hydrogen or hydroxyl, or R5 represents a double bond between carbon atom X and one of the neighbouring carbon atoms; R4 is phenyl, benzofuranyl, benzo- dioxanyl, benzodioxepanyl or benzoyl, which groups may be substituted with a group (R)n, wherein R and n have the above meanings; A is a pyrrole ring or a pyrazole ring, with the proviso that the phenyl group is in the meta position with respect to the alkylamino substituent, which rings may be substituted with a phenyl group which can optionally be substituted with a group (R)n; and the acid addition salts and prodrugs thereof.
530424
Kruse Cornelis G.
Tulp Martinus T.m.
Van Der Heyden Johannes A.m.
Van Wijngaarden Ineke
Duphar International Research B.v.
Fetherstonhaugh & Co.
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