Aryl-substituted nitrogen-containing heterocyclic compound

Details Aryl-substituted nitrogen-containing heterocyclic compound Aryl-substituted nitrogen-containing heterocyclic compound

C - Chemistry, Metallurgy

07

D

C07D 207/335 (2006.01) A61K 31/402 (2006.01) A61K 31/415 (2006.01) A61K 31/4155 (2006.01) A61K 31/417 (2006.01) A61K 31/4439 (2006.01) A61P 3/04 (2006.01) A61P 9/02 (2006.01) A61P 13/02 (2006.01) A61P 25/04 (2006.01) A61P 25/14 (2006.01) A61P 25/16 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 25/36 (2006.01) A61P 43/00 (2006.01) C07D 231/12 (2006.01) C07D 233/64 (2006.01) C07D 401/04 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2624162

Disclosed is an aryl-substituted nitrogen-containing heterocyclic compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. This compound serves as a nociceptin receptor antagonist and is useful as a pharmaceutical agent for treating diseases associated with a nociceptin receptor. (I) [In the formula, A1, A2 and A3 independently represent a carbon atom or a nitrogen atom, and one or two of A1, A2 and A3 represent a carbon atom; R1 represents a lower alkyl group or the like; R2 represents a phenyl group which may be substituted by a halogen atom or the like; R3 represents a hydrogen atom, a lower alkyl group or the like; and R4 represents a lower alkyl group or the like.]

La présente invention concerne un composé hétérocyclique azoté substitué par un groupe aryle représenté par la formule (I) ci-dessous ou un sel pharmaceutiquement acceptable de celui-ci. Ce composé sert d'antagoniste de récepteur de nociceptine et est utile comme agent pharmaceutique pour traiter des maladies liées à un récepteur de nociceptine. (I) [Dans la formule, A1, A2 et A3 représentent indépendamment un atome de carbone ou un atome d'azote, et un ou deux parmi A1, A2 et A3 représentent un atome de carbone ; R1 représente un groupe alkyle inférieur ou analogues ; R2 représente un groupe phényle qui peut être substitué par un atome d'halogène ou analogues ; R3 représente un atome d'hydrogène, un groupe alkyle inférieur ou analogues ; et R4 représente un groupe alkyle inférieur ou analogues.]

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