C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/38 (2006.01) A61K 31/44 (2006.01) A61K 31/4406 (2006.01) A61K 31/505 (2006.01) C07D 213/61 (2006.01) C07D 213/62 (2006.01) C07D 213/64 (2006.01) C07D 213/65 (2006.01) C07D 213/73 (2006.01) C07D 239/26 (2006.01)
Patent
CA 2334923
Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5- (3-pyridyl) -4-penten-2-amine, (4E) -N-methyl-5- (5-pyrimidinyl) -4-penten-2- amine, (4E)-N-methyl-5-( 5-methoxy-3-pyridyl) -4-penten-2-amine, (4E)-N- methyl-5- (6-amino-5-methyl -3-pyridyl)-4-penten -2- amine, (2R)-(4E) -N-methyl-5-(3-pyridyl) -4-penten-2-amine, (2R)-(4E)-N- methyl-5-(5- isopropoxy-3-pyridyl) -4-penten-2- amine, (4E)-N-methyl -5-(5-bromo-3-pyridyl) -4-penten-2-amine, (4E)-N-methyl -5-(5-ethoxy-3- pyridyl)-4-penten- 2-amine, (2S)-(4E)-N- methyl-5-(3-pyridyl) -4-pen- ten-2-amine, (4E)-N-methyl -5-(5-isopropoxy-3- pyridyl)-4- penten-2-amine and (2S)-(4E)-N-methyl -5-(5-isopropoxy -3-pyridyl) -4-penten-2-amine.
L'invention concerne des composés comprenant une amine oléfinique à substitution aryle. Les composés représentatifs de l'invention sont les suivants: (4E)-N-méthyle-5-(3-pyridyle)-4-pentène-2-amine, (4E)-N-méthyle-5-(5-pyrimidinyle)-4-pentène-2-amine, (4E)-N-méthyle-5-(5-méthoxy-3-pyridyle)-4-pentène-2-amine, (2R)-(4E)-N-méthyle-5-(3-pyridyle)-4-pentène-2-amine, (4E)-N-méthyle-5-(6-amino-5-méthyle-3-pyridyle)-4-pentène-2-amine, (2R)-(4E)-N-méthyle-5-(3-pyridyle)-4-pentène-2-amine, (2R)-(4E)-N-méthyle-5-(5-isopropoxy-3-pyridyle)-4-pentène-2-amine, (4E)-N-méthyle-5-(5-bromo-3-pyridyle)-4-pentène-2-amine, (4E)-N-méthyle-5-(5-éthoxy-3-pyridyle)-4-pentène-2-amine, (2S)-(4E)-N-méthyle-5-(3-pyridyle)-4-pentène-2-amine, (4E)-N-méthyle-5-(5-isopropoxy-3-pyridyle)-4-pentène-2-amine et (2S)-(4E)-N-méthyle-5-(5-isopropoxy-3-pyridyle)-4-pentène-2-amine.
Bencherif Merouane
Bhatti Balwinder Singh
Caldwell William Scott
Crooks Peter Anthony
Dull Gary Maurice
R.j. Reynolds Tobacco Company
Robic
Targacept Inc.
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