Aryl-substituted piperazine derivatives

Details Aryl-substituted piperazine derivatives Aryl-substituted piperazine derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/00 (2006.01)

Patent

CA 2567604

Aryl-substituted piperazine derivatives are provided. Such compounds may be used to modulate MCH receptor activity in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).

L'invention concerne des dérivés pipérazine à substitution aryle, pouvant être utilisés pour moduler l'activité de récepteur MCH in vivo ou in vitro, et utiles en particulier dans le traitement de divers troubles métaboliques, de l'alimentation et sexuels, chez l'homme, les animaux domestiques et les animaux d'élevage. On décrit des compositions pharmaceutiques et des procédés permettant de traiter ces troubles, ainsi que des procédés d'utilisation de tels ligands pour la détection de récepteur MCH (par exemple, dans les études de localisation de récepteur).

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