C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/38 (2006.01) A61K 31/4155 (2006.01) C07D 231/18 (2006.01) C07D 401/04 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2524321
The present invention relates to compounds having the formula (I), and pharmaceutically-acceptable salts, prodrugs, solvates, isomers, and/or hydrates thereof, wherein Q is an optionally-substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl, or pyrazinyl ring; R2 is alkyl or an amino group as defined herein; and Z is optionally-substituted oxadiazolyl or - C(=O)NR6, wherein R6 is lower alkyl or cyclopropyl. The compounds are surprisingly advantageous in preparing medicaments for treating p38 kinase related conditions and/or in preparing medicaments for use in treating inflammatory disorders or conditions in a patient.
La présente invention concerne des composés de formule (I) et des sels pharmaceutiquement acceptables, des promédicaments, des solvats, des isomères et/ou des hydrates desdits composés. Dans ladite formule, Q est un noyau phényle, pyridyle, pyridazinyle, pyrimidinyle ou pyrazinyle éventuellement substitué; R¿2? est alkyle ou un groupe amino défini dans le mémorandum descriptif; et Z est oxadiazolyle ou -C(=O)NR¿6? (R¿6? étant alkyle inférieur ou cyclopropyle). Les composés de l'invention sont étonnamment avantageux dans la préparation de médicaments destinés à traiter des états liés à la kinase p38 et/ou des troubles ou états inflammatoires chez un patient.
Chen Bang-Chi
Das Jagabandhu
Dyckman Alaric
Leftheris Katerina
Liu Chunjian
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
LandOfFree
Aryl-substituted pyrazole-amide compounds useful as kinase... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aryl-substituted pyrazole-amide compounds useful as kinase..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aryl-substituted pyrazole-amide compounds useful as kinase... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1404883