A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61K 31/421 (2006.01) A61K 31/426 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) C07D 207/30 (2006.01) C07D 207/416 (2006.01) C07D 231/10 (2006.01) C07D 231/12 (2006.01) C07D 233/54 (2006.01) C07D 235/18 (2006.01) C07D 263/34 (2006.01) C07D 277/56 (2006.01) C07D 403/00 (2006.01) C07D 403/04 (2006.01) C07D 413/00 (2006.01)
Patent
CA 2368631
This invention relates to compounds having Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5-R13 are set in the specification. The invention also is directed to the use of compounds of Formula (I) for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
L'invention concerne de composés correspondant à la formule (I) ou leurs sels, promédicaments ou solvates pharmaceutiquement acceptables, dans laquelle Het et R¿5?-R¿13? sont spécifiés dans la description. L'invention concerne également l'utilisation de composés de formule (I) pour traiter les lésions neuronales consécutives à une ischémie globale ou focale, pour traiter ou prévenir des états neurodégénératifs tels que la sclérose latérale amyotrophique (ALS), pour traiter, prévenir ou améliorer une douleur chronique ou aiguë et pour traiter ou prévenir la neuropathie diabétique. Ces composés sont notamment des agents anti-acouphènes, des anticonvulsivants, des anti-maniaco-dépresseurs, des anesthésiques locaux et des antiarythmiques.
Hogenkamp Derk J.
Nguyen Phong
Upasani Ravindra
Euro-Celtique S.a.
Mbm & Co.
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