Aryl substituted pyrazoles, triazoles and tetrazoles, and...

Details Aryl substituted pyrazoles, triazoles and tetrazoles, and... Aryl substituted pyrazoles, triazoles and tetrazoles, and...

C - Chemistry, Metallurgy

07

D

C07D 231/12 (2006.01) A61K 31/415 (2006.01) A61K 31/4196 (2006.01) A61P 23/00 (2006.01) A61P 25/08 (2006.01) C07D 249/08 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2400778

This invention relates to compounds having the Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5 - R8 are set in the specification. The invention also is directed to the use of compounds of Formula (I) for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

L'invention concerne des composés de formule (I) ou un sel pharmaceutiquement acceptable, un promédicament ou un solvate desdits composés. Dans cette formule, Het et R¿5?-R¿8? sont tels que définis dans le descriptif. L'invention concerne également l'utilisation de composés de formule (I) pour traiter une lésion neuronale consécutive à une ischémie globale ou focale, pour traiter ou prévenir des états neurodégénératifs tels que la sclérose latérale amyotrophique (SLA), et pour traiter, prévenir ou améliorer une douleur aiguë ou chronique. Ces composés sont notamment des agents anti-acouphènes, des anticonvulsivants, des anti-maniaco-dépresseurs, des anesthésiques locaux et des anti-arythmisants. Ils peuvent également être destinés au traitement ou à la prévention de la neuropathie diabétique.

Affiliated with

Also associated with

Rating

Aryl substituted pyrazoles, triazoles and tetrazoles, and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aryl substituted pyrazoles, triazoles and tetrazoles, and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aryl substituted pyrazoles, triazoles and tetrazoles, and... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1886264