C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/82 (2006.01) A61K 31/4418 (2006.01) A61P 9/06 (2006.01) A61P 23/00 (2006.01) A61P 25/08 (2006.01) C07D 213/81 (2006.01)
Patent
CA 2459527
This invention relates aryl substituted pyridines of Formula (I),or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1-R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
Cette invention concerne des pyridines substitués par aryle de la formule (I) ou un sel, promédicament ou solvat pharmaceutiquement acceptable desdits composés, dans lesquels Ar et R¿1?-R¿4? sont tels que décrits dans le mémorandum descriptif. L'invention concerne également l'utilisation de composés de la formule (I) pour le traitement de lésions neuronales consécutives à une ischémie générale ou focale, pour le traitement ou la prévention d'affections neurodégénératives, telles que la sclérose latérale amyotrophique (ALS), et pour le traitement, la prévention ou l'amélioration de la douleur tant aiguë que chronique. L'invention concerne en outre l'utilisation de composés de la formule (I) comme anti-acouphènes, anticonvulsifs, antidépresseurs antimaniaques, anesthésiques locaux, ou comme ranti-arythmisant, et pour le traitement ou la prévention de la neuropathie diabétique.
Goehring R. Richard
Shao Bin
Sun Qun
Victory Samuel F.
Euro-Celtique S.a.
Mbm Intellectual Property Law Llp
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