Aryl substituted pyridines, pyrimidines, pyrazines and...

Details Aryl substituted pyridines, pyrimidines, pyrazines and... Aryl substituted pyridines, pyrimidines, pyrazines and...

C - Chemistry, Metallurgy

07

D

C07D 213/81 (2006.01) A61K 31/505 (2006.01) A61P 25/08 (2006.01) C07D 239/28 (2006.01) C07D 239/38 (2006.01) C07D 241/24 (2006.01) C07D 251/24 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2400945

This invention relates aryl substituted pyridines, pyrimides, pyrazines and triazines of Formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A1, A2, A3, R1-R4, X and Y are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhytmics and for the treatment of prevention of diabetic neuropathy.

L'invention concerne des pyridines, pyrimidines, pyrazines et triazines substituées par aryle et représentées par la formule (I), ou un de leurs sels, promédicaments ou solvates acceptables sur le plan pharmaceutique, A1, A2, A3, R1-R4, X et Y étant définis dans la description. L'invention concerne également l'utilisation de composés représentés par la formule (I) servant à traiter la dégénérescence neuronale suivant une ischémie globale ou focale, à traiter ou à prévenir des états neurodégénératifs, tels que la sclérose latérale amyotrophique (ALS), ainsi qu'à traiter, à prévenir ou à améliorer la douleur à la fois aigüe et chronique, sous forme d'agents anti-acouphènes, anticonvulsifs et dépresseurs antimaniaques, anesthésiques locaux, antiarrhythmiques, et à traiter ou à prevenir la neuropathie diabétique.

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