Aryl thiopyrano¬4,3,2-cd|indoles as inhibitors of...

Details Aryl thiopyrano¬4,3,2-cd|indoles as inhibitors of... Aryl thiopyrano¬4,3,2-cd|indoles as inhibitors of...

C - Chemistry, Metallurgy

07

D

C07D 495/06 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2099060

269/GL115 18735 TITLE OF THE INVENTION ARYL THIOPYRANO[4,3,2-cd]INDOLES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS ABSTRACT OF THE DISCLOSURE Compounds having the formula I: Image I are inhibitors of the 5-lipoxygenase enzyme and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti- allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, psoriasis, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.

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