Aryl ureas as kinase inhibitors

Details Aryl ureas as kinase inhibitors Aryl ureas as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/79 (2006.01) A61K 31/44 (2006.01) A61P 11/00 (2006.01) A61P 19/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07D 213/81 (2006.01) C07D 213/89 (2006.01)

Patent

CA 2475818

This invention relates to new aryl ureas of formula (I) and methods for their synthesis. The compounds are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VEGF mediated diseases such as angiogenesis disorders.

L'invention concerne des aryle-urées de formule (I) ainsi que des procédés destinés à les synthétiser. Ces composés sont utiles dans le traitement (i) de maladies à médiation raf, par exemple le cancer, (ii) de maladies à médiation p38 telles que l'ostéoporose et les affections inflammatoires, et (iii) de maladies à médiation VEGF telles que les troubles de l'angiogénèse.

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