Aryl ureido derivatives and their medical use

Details Aryl ureido derivatives and their medical use Aryl ureido derivatives and their medical use

C - Chemistry, Metallurgy

07

C

C07C 275/42 (2006.01) A61K 31/17 (2006.01) A61K 31/19 (2006.01) A61K 31/381 (2006.01) A61K 31/416 (2006.01) A61K 31/4245 (2006.01) A61K 31/44 (2006.01) C07C 309/46 (2006.01) C07C 309/51 (2006.01) C07D 209/40 (2006.01) C07D 213/72 (2006.01) C07D 213/75 (2006.01) C07D 231/56 (2006.01) C07D 257/04 (2006.01) C07D 271/07 (2006.01) C07D 317/66 (2006.01) C07D 333/36 (2006.01)

Patent

CA 2502705

This invention relates to novel aryl ureido benzoic acid derivatives useful as selective and non-competitive antagonists of the ionotropic GluR5 receptor. Due to their biological activity, the aryl ureido derivatives of the invention are considered useful for treating diseases that are responsive to modulation of an aspartate or a glutamate receptor. Moreover the invention provides chemical compounds for use according to the invention, as well as pharmaceutical compositions comprising the chemical compounds, and methods of treating diseases or disorders or conditions responsive to modulation of an aspartate or a glutamate receptor.

L'invention concerne des nouveaux dérivés d'acide aryl uréido benzoïque utiles en tant qu'antagonistes sélectifs et non compétitifs du récepteur ionotropique GluR5. En raison de leur activité biologique, les dérivés aryl uréido de l'invention sont considérés comme étant utiles pour le traitement de maladies qui sont sensibles à une modulation d'un récepteur de l'aspartate ou du glutamate. L'invention concerne en outre des composés chimiques destinés à être utilisés dans le cadre de l'invention, ainsi que des compositions pharmaceutiques comprenant ces composés chimiques, et des procédés de traitement de maladies, de troubles ou d'états sensibles à la modulation d'un récepteur de l'aspartate ou du glutamate.

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