Arylacetic acid derivatives

Details Arylacetic acid derivatives Arylacetic acid derivatives

C - Chemistry, Metallurgy

07

C

167/179, 260/509

C07C 59/90 (2006.01) A61K 31/19 (2006.01) C07C 59/52 (2006.01) C07C 69/732 (2006.01) C07C 205/56 (2006.01)

Patent

CA 1276938

Abstract A compound having a potentially inhibitory effect on 15-hydroxy-prostaglandin dehydrognase IPGDH) and having the formula Image (I) in which R1 and R2 are hydrogen or lower alkyl; R3 is hydrogen, lower alkyl or substituted or un- substituted phenyl; R4, R5 and R6 are hydrogen, halogen, lower alkyl, lower alkoxy, cyano, carboxy or nitro; at least one of the groups R4 to R6 being hydrogen; R7 to R11 are hydrogen, halogen, cyano, lower alkyl, trifluoromethyl, lower alkoxy, hydroxy, lower acyl, lower alkoxycarbonyl, N,N,-diloweralkyl-aminocarbonyl or N,N-loweralkylene-aminocarbonyl; and R8 to R10 may in addition be carboxy; at least two of R7 to R11 always being hydrogen; and -A- is -CO-, -CH2-CO-, -CH=CH-, -CH=CH-CO- or corres- ponding groups in which a hydrogen atom is replaced by a lower alkyl group. The invention comprises also lactones of those compounds in which R1 is hydrogen, and salts of those compounds which contain at least one carboxy group.

472414

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