Arylalkanoic acid resolution

C - Chemistry – Metallurgy – 12 – P

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C12P 41/00 (2006.01) C12P 7/40 (2006.01)

Patent

CA 2116004

2116004 9304190 PCTABS00020 In a process for preparing predominantly one enantiomer of an optically-active 2-arylalkanoic acid by biotransformation, using an appropriate enzyme, of a mixture of enantiomers of an ester of the acid, the ester is derived from an alcohol of more than 4 carbon atoms, and the enzyme is in crude or only partially purified form. For example, S-ketoprofen can be thus prepared economically and in high ee, from racemic octyl ketoprofen.

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