C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/06 (2006.01) C07D 207/16 (2006.01) C07D 277/06 (2006.01) C07D 403/06 (2006.01) C07D 405/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2084204
ABSTRACT Relating to an arylalkanoylamine derivative having an excellent prolyl endopeptidase inhibitory action and resistances to hypoxia and amnesia and being represented by the following general formula (I): Image (I) (wherein A represents indanyl group, indenyl group, 1,2,3,4- tetrahydronaphthalenyl group or benzofuranyl group; m represents an integer of 0 to 5; Z represents hydroxymethyl group, formyl group, nitrile group, hydroxyiminomethyl group, semicarbazonomethyl group or dialkoxymethyl group; X and Y may be the same or different, and individually represent methylene group or sulfur atom, except for the case wherein A represents indanyl group, indenyl group, or 1,2,3,4-tetrahydronaphthalenyl group; X and Y both represent methylene group; Z represents hydroxymethyl group or formyl group, and a drug for improving mneme, cerebral circulation and cerebral metabolism with the effective ingredient thereof being the arylalkanoylamine derivative.
Arai Heihachiro
Kato Hisayoshi
Nakata Naoki
Nishioka Hiroyasu
Okubo Akihiro
Gowling Lafleur Henderson Llp
Zeria Pharmaceutical Co. Ltd.
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