Arylalkanoylpyridazines

Details Arylalkanoylpyridazines Arylalkanoylpyridazines

C - Chemistry, Metallurgy

07

D

C07D 237/04 (2006.01) A61K 31/50 (2006.01) C07D 405/04 (2006.01)

Patent

CA 2335104

Arylalkanoylpyridazine derivatives of the formula I Image and their physiologically acceptable salts and solvates, in which R1, R2, Q and B have the meanings indicated in Claim 1, show an inhibition of phosphodiesterase IV and can be employed for the treatment of asthma, chronic bronchitis, atopic dermatitis, psoriasis and other skin diseases, inflammatory diseases, autoimmune disorders, such as, for example, rheumatoid arthritis, multiple sclerosis, Crohn's disease, diabetes mellitus or ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, tumour growth or tumour metastases, sepsis, memory disorders, atherosclerosis and AIDS.

L'invention concerne des dérivés d'arylalcanoylpyridazines de formule (I), ainsi que leurs sels et solvates physiologiquement tolérables. Dans la formule (I), R<1>, R<2>, Q et B ont la signification indiquée dans la revendication 1. Ces composés exercent une action inhibitrice sur la phosphodiestérase IV et peuvent être utilisés pour traiter des affections allergiques, l'asthme, la bronchite chronique, la dermatite atopique, le psoriasis et d'autres maladies de la peau, des maladies infectieuses, des maladies auto-immunes, telles que la polyarthrite rhumatoïde, la sclérose en plaques, la maladie de Crohn, le diabète sucré ou la rectocolite hémorragique, l'ostéoporose, les réactions de rejet de greffes, la cachexie, la croissance tumorale ou les métastases, la septicémie, les troubles de la mémoire, l'athérosclérose et le SIDA.

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