Arylalkyl indoles having serotonin receptor affinity useful...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/04 (2006.01) A61K 31/40 (2006.01) A61P 5/00 (2006.01) C07D 209/00 (2006.01)

Patent

CA 2490115

The present invention relates to novel tetracyclic arylalkyl indoles, their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel tetracyclic arylalkyl of the general formula (I), their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention also relates to process/es for preparing such compound/s of general formula (I), composition/s containing effective amount/s of such a compound and the use of such a compound/composition in therapy.

L'invention concerne de nouveaux arylalkyl indoles tétracycliques, leurs dérivés, leurs analogues, leurs formes tautomères, leurs stéréoisomères, leurs polymorphes, leurs sels pharmaceutiquement acceptables, leurs solvates pharmaceutiquement acceptables, de nouveaux intermédiaires et des compositions pharmaceutiquement acceptables contenant lesdits indoles. L'invention concerne, plus particulièrement, de nouveaux arylalkyles tétracycliques représentés par la formule (I), leurs dérivés, leurs analogues, leurs formes tautomères, leurs stéréoisomères, leurs polymorphes, leurs sels pharmaceutiquement acceptables, leurs solvates pharmaceutiquement acceptables, de nouveaux intermédiaires et des compositions pharmaceutiquement acceptables contenant lesdits indoles. L'invention concerne enfin un ou des procédé(s) permettant de préparer le ou les composé(s) représenté(s) par la formule (I), une ou des composition(s) contenant une ou des quantité(s) de composé et l'utilisation de ce composé ou de cette composition en thérapie.

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