C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/30 (2006.01) A61K 31/4406 (2006.01) A61P 25/00 (2006.01) C07D 213/32 (2006.01) C07D 213/61 (2006.01) C07D 213/65 (2006.01) C07D 215/20 (2006.01) C07D 239/26 (2006.01) C07D 453/02 (2006.01)
Patent
CA 2383307
Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need arylalkyloxyalkylamine and arylalkylthioalkylamine compounds, including arylmethoxyalkylamines and arylmethylthioalkylamines, such as pyridylmethoxyalkylamines and pyridylmethylthio alkylamines. Exemplary compounds include methyl(3-(3-pyridylmethoxy)propyl)amine, 3- pyridyl(pyrrolidin-2-ylmethoxy)methane, methyl(1-methyl-2-(3- pyridylmethoxy)ethyl)amine, (3-((3-pyridyl)methoxy)propyl)dimethylamine, (2- ((5-bromo-3-pyridyl)methoxy)ethyl)methylamine, methyl(2-((5-methoxy-3- pyridyl)methoxy)ethyl)amine, (2-((3-quinolyl)methoxy)ehtyl)methylamine, methyl(2-(pyrimidin-5-ylmethoxy)ethyl)amine, 3-((3- pyridyl)methoxy)quinuclidine, (3-pyridyl)quinuclidin-2-ylmethoxy)methane, (3- pyridyl)(pyrrolidin-2-ylmethylthio)methane and (2-((3- pyridyl)methylthio)ethyl)methylamine.
On traite des patients susceptibles de souffrir ou souffrant de pathologies et de troubles, tels que des troubles du système nerveux central, en leur administrant des composés arylalkyloxyalkylamines et arylalkylthioalkylamines, qui comprennent des arylméthoxyalkylamines et des arylméthylthioalkylamines, tels que des pyridylméthoxyalkylamines et des pyridylméthylthio alkylamines. Des composés de l'invention comprennent méthyl(3-(3-pyridylméthoxy)propyl)amine, 3-pyridyl(pyrrolidin-2-ylméthoxy)méthane, méthyl(1-méthyl-2-(3-pyridylméthoxy)éthyl)amine, (3-((3-pyridyl)méthoxy)propyl)diméthylamine, (2-((5-bromo-3-pyridyl)méthoxy)éthyl)méthylamine, méthyl(2-((t-méthoxy-3-pyridly)méthoxy)éthyl)amine, (2-((3-quinolyl) méthoxy)éthyl)méthylamine, méthyl(2-(pyrimidin-5-ylméthoxy)éthyl)amine, 3-((3-pyridyl)méthoxy)quinuclidine, (3-pyridyl)quinuclidin-2-ylméthoxy)méthane, (3-pyridyl)pyrrolidin-2-ylméthylthio)méthane et (2-((3-pyridyl)méthylthio)éthyl) méthylamine.
Dull Gary Maurice
Wagner Jared Miller
Bereskin & Parr
Dull Gary Maurice
Targacept Inc.
Wagner Jared Miller
LandOfFree
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