Arylating medicaments

Details Arylating medicaments Arylating medicaments

A - Human Necessities

61

K

A61K 31/19 (2006.01) A61K 31/04 (2006.01) A61K 31/05 (2006.01) A61K 31/06 (2006.01) A61K 31/085 (2006.01) A61K 31/135 (2006.01) A61K 31/165 (2006.01) A61K 31/185 (2006.01) A61K 31/192 (2006.01) A61K 38/06 (2006.01) C07C 63/70 (2006.01) C07C 205/06 (2006.01) C07C 205/12 (2006.01) C07C 205/24 (2006.01) C07C 205/37 (2006.01) C07C 205/57 (2006.01) C07C 205/58 (2006.01) C07C 211/52 (2006.01) C07C 237/30 (2006.01) C07C 309/39 (2006.01) C07C 309/40 (2006.01) C07C 309/46 (2006.01) C07K 5/02 (2006.01)

Patent

CA 2163459

Various arylating agents having activity in the treatment of cancer and viral infection are disclosed. The active compounds include an aromatic ring having at least one labile leaving group and at least one electrophilic group. Preferred active compounds include chlorobenzenesulphonic acids and optionally halogenated nitrobenzene compounds. In an anti-viral context, the active compounds have efficacy against HIV infections.

Différents agents d'arylation présentant une activité en ce qui concerne le traitement du cancer et des infections virales sont décrits. Ces composés actifs comprennent un noyau aromatique contenant au moins un groupe labile et au moins un groupe électrophile. Les composés actifs préférés comprennent les acides chlorobenzène-sulfoniques ainsi que des composés de nitrobenzène éventuellement halogénés. Dans un contexte antiviral, ces composés actifs agissent efficacement contre les infections par VIH.

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