C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/77 (2006.01) A61K 31/165 (2006.01) A61K 31/381 (2006.01) A61K 31/44 (2006.01) A61P 35/00 (2006.01) C07C 237/42 (2006.01) C07C 275/24 (2006.01) C07D 213/82 (2006.01) C07D 333/38 (2006.01)
Patent
CA 2507137
The present invention describes compounds of general formula (I), a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutical agents. The compounds according to this invention show antiproliferative and differentiation- inducing activity, which results in inhibition of tumor cell proliferation, induction of apoptosis and inhibition of invasion.
La présente invention concerne des composés de formule générale (I), un procédé pour les produire, des médicaments les contenant, ainsi que l'utilisation de ces composés en tant qu'agents pharmaceutiques. Les composés selon cette invention présentent une activité d'antiprolifération et d'induction de différenciation qui permet d'inhiber une prolifération de cellules tumorales, d'induire une apoptose et d'inhiber une invasion.
Fertig Georg
Herting Frank
Koerner Matthias
Kubbies Manfred
Limberg Anja
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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