Arylethers, their manufacture and methods of treatment

Details Arylethers, their manufacture and methods of treatment Arylethers, their manufacture and methods of treatment

C - Chemistry, Metallurgy

07

C

C07C 257/10 (2006.01) A61K 31/155 (2006.01) C07C 257/18 (2006.01) C07C 271/64 (2006.01) C07C 311/54 (2006.01) C07C 323/45 (2006.01)

Patent

CA 2070796

4-18680/A/CGC 1559 ARYLETHERS,THEIR MANUFACTURE AND METHODS OF TREATMENT Abstract of the Invention The invention relates to the compounds of the formula Image (I) and pharmaceutically acceptable salts thereof, in which: R is hydrogen or an acyl radical which is derived from an organic carbonic acid, an organic carboxylic acid, a sulfonic acid, or a carbonic acid; R1 is a substitment selected from an aliphatic hydrocarbon radical, an araliphatic hydrocarbon radical and a cycloaliphatic hydrocarbon radical; X1 and X3, independently of one another, are oxygen (-O-) or sulphur (-S-); and X2 is a divalent aliphatic hydrocarbon radical which may be interrupted by an aromatic radical; wherein the phenyl rings of formula I may be, independently of one another, further substituted by one or more substituents selected from halogen, trifluoromethyl, an aliphatic hydrocarbon radical, hydroxy, and hydroxy which is etherified by an aliphatic, araliphatic or cycloaliphatic alcohol or which is esterified by an aliphatic or araliphatic carboxylic acid; wherein aryl in the above definitions may be, independently of one another, further substituted by one or more substituents selected from halogen, trifluoromethyl, an aliphatic hydrocarbon radical, hydroxy and hydroxy which is etherified by an aliphatic, araliphatic or cycloaliphatic alcohol or which is esterified by an aliphatic or araliphatic carboxylic acid; and wherein a cycloaliphatic hydrocarbon radical may be substituted by an aliphatic radical. The compounds are useful as selective LTB-4 receptor antagonists in the treatment of conditions or syndromes in mammals which are responsive Lo LTB-4 receptor antagonism.

Affiliated with

Also associated with

Rating

Arylethers, their manufacture and methods of treatment does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Arylethers, their manufacture and methods of treatment, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Arylethers, their manufacture and methods of treatment will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1894530