Arylhydrazone derivatives useful as antibacterial agents

Details Arylhydrazone derivatives useful as antibacterial agents Arylhydrazone derivatives useful as antibacterial agents

C - Chemistry, Metallurgy

07

C

C07C 255/66 (2006.01) A61K 31/265 (2006.01) A61K 31/275 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07C 311/08 (2006.01) C07C 311/13 (2006.01) C07C 317/32 (2006.01) C07C 317/34 (2006.01) C07C 323/28 (2006.01) C07C 323/48 (2006.01) C07C 327/58 (2006.01) C07C 327/60 (2006.01) C07D 209/20 (2006.01) C07D 213/57 (2006.01) C07D 213/61 (2006.01) C07D 213/77 (2006.01) C07D 215/14 (2006.01) C07D 217/16 (2006.01) C07D 241/12 (2006.01) C07D 307/

Patent

CA 2229414

The subject invention provides arylhydrazone compounds having formula (I), wherein A and B are independently aryl or heteroaryl and A and B independently are substituted with at least one group selected from alkyl, halogen, CN, COOR7, NR7R8, CONR7R8, NO2, SR7, SOR7, SO2R7, NHCOR7, NHSO2R7, OR7, hydroxyalkyl, and aminoalkyl. The compounds of this invention are useful for treating a wide variety of bacterial infections, including diseases of the skin, e.g., acne and skin ulcers, gastroenteritis, colitis, meningitis, keratinitis, conjunctivitis, diseases of the urinary and genital tracts, etc.

La présente invention concerne des composés d'arylhydrazones représentés par la formule I, dans laquelle A et B sont, indépendamment l'un de l'autre, aryle ou hétéroaryle et sont substitués avec au moins un groupement choisi parmi: alkyle, halogène, CN, COOR?7¿, NR?7¿R?8¿, NO¿2?, SR?7¿, SOR?7¿, SO¿2?R?7¿, NHCOR?7¿, NHSO¿2?R?7¿, OR?7¿, hydroxyalkyle et aminoalkyle. Les composés selon l'invention sont utiles pour traiter des infections bactériennes très diverses, y compris des affections cutanées, par exemple l'acné et les ulcères cutanés, les gastro-entérites, les colites, les méningites, la kératite, la conjonctivite, les affections de l'appareil uro-génital, etc.

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