Arylmalonamido methoxycephalosporins

Details Arylmalonamido methoxycephalosporins Arylmalonamido methoxycephalosporins

C - Chemistry, Metallurgy

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C07D 501/36 (2006.01) A61K 31/545 (2006.01) C07D 501/56 (2006.01) C07D 501/57 (2006.01) C07D 501/60 (2006.01)

Patent

CA 1089848

ARYLMALONAMIDOMETHOXYCEPHALOSPORINS ABSTRACT Antibacterial 7.beta.-arylmalonamido-7.alpha.-methoxy-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids of the formula: Image (wherein Ar is heterocyclic group or p-oxysubstituted phenyl; COB1 and COB2 each is carboxy or protected carboxy; and Het is an optionally substituted heterocyclic group.) preparable e.g. from 7.beta.-amino-7.alpha.-methoxy-3-heterocyclic thiomethyl-3-cephem-4-carboxy- lic acid derivatives by acylation with arylmalonic acid or reac- tive derivatives thereof, or from some other materials, are useful as an active ingredient of an antibacterial pharmaceutical prepara- tion in combination with a conventional pharmaceutical carrier.

283809

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