Arylmethyl triazolo and imidazopyrazines as c-met inhibitors

Details Arylmethyl triazolo and imidazopyrazines as c-met inhibitors Arylmethyl triazolo and imidazopyrazines as c-met inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4985 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2530589

The present invention relates to compounds of the Formulae (I) - (IV), wherein R1 - R6, R11 - R13, X and Y are defined herein, and their pharmaceutically acceptable salts. These compounds modulate the activity of c-Met and are therefore expected to be useful in the prevention and treatment of c-Met related disorders such as cancer.

La présente invention concerne des composés des formules (I)-(IV), dans lesquelles R¿1?-R¿6?, R¿11?-R¿13?, X et Y ont la notation ci-définie, et leurs sels pharmaceutiquement acceptables. Ces composés modulent l'activité de c-Met et on s'attend par conséquent qu'ils soient utiles dans la prévention et dans le traitement de troubles liés à c-MET tels que le cancer.

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