C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 217/18 (2006.01) A61K 31/138 (2006.01) A61K 31/44 (2006.01) A61K 31/4409 (2006.01) A61P 25/02 (2006.01) C07C 217/16 (2006.01) C07C 217/20 (2006.01) C07D 213/68 (2006.01)
Patent
CA 2704250
The present invention relates generally to the field of therapeutic treatment and compounds having utility therefor, in particular the therapy or management of conditions associated with excessive, unwanted or undesirable sodium ion passage through cellular membranes via voltage-gated sodium channels. In one embodiment the invention is concerned with the treatment of neuropathic pain. The invention contemplates to aryloxy-substituted amines, as sodium channel blockers or modulators. In further embodiments, the invention also relates to compounds which may advantageously have dual sodium channel blocker/modulating and antioxidative (free-radical scavenging) effects. Methods for their manufacture and compositions containing the compounds are also contemplated.
La présente invention concerne d'une manière générale le domaine du traitement thérapeutique et les composés ayant une utilité à ce sujet, en particulier la thérapie ou la gestion d'états associés à un passage d'ions sodium excessif, indésiré ou indésirable à travers des membranes cellulaires par les canaux sodiques sensibles à la tension. Dans un mode de réalisation, l'invention porte sur le traitement d'une douleur neuropathique. L'invention envisage des amines substituées par aryloxy, comme agents de blocage ou modulateurs des canaux sodiques. Dans d'autres modes de réalisation, l'invention porte également sur des composés qui peuvent avantageusement avoir des effets doubles de blocage/modulation des canaux sodiques et antioxydants (piégeage des radicaux libres). L'invention porte également sur des procédés permettant de les fabriquer et sur des compositions contenant les composés.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Howard Florey Institute
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