Aryloxy and arylacyloxy methyl ketones as thiol protease...

Details Aryloxy and arylacyloxy methyl ketones as thiol protease... Aryloxy and arylacyloxy methyl ketones as thiol protease...

C - Chemistry, Metallurgy

07

K

167/248, 167/103

C07K 5/06 (2006.01) A61K 31/21 (2006.01) C07C 271/22 (2006.01) C07K 5/065 (2006.01) C07K 5/078 (2006.01) C07K 5/087 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1329862

ABSTRACT OF THE DISCLOSURE Thiol protease inhibitors are disclosed having the formula: Image (I) or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein: n is 0 or 1; m is 0, 1 or 2; X is H or an N-protecting group; each Y is independently an optionally protected .alpha.-amino acid residue; R is an optionally protected .alpha.-amino acid side chain that is H or CH3 of that is bonded to the .alpha.-carbon atom to which it is attached by a methylene, methine or phenyl radical; and R' is optionally substituted aryl.

554950

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