Aryloxy and arylalkyleneoxy substituted imidazoquinolines

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/04 (2006.01) A61K 31/4745 (2006.01) A61K 31/5377 (2006.01)

Patent

CA 2536136

Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy or hydroxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

La présente invention concerne des composés d'imidazoquinoline présentant un substituant aryloxy, arylalkylèneoxy ou hydroxy en position 6, 7, 8 ou 9, des compositions pharmaceutiques contenant ces composés, des produits intermédiaires et des procédés pour utiliser ces composés comme immunomodulateurs afin de moduler la biosynthèse de cytokine chez des animaux et de traiter des maladies, notamment des maladies virales et néoplasiques.

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