Aryloxyalkyl containing compounds

Details Aryloxyalkyl containing compounds Aryloxyalkyl containing compounds

C - Chemistry, Metallurgy

07

C

260/292, 260/295

C07C 69/736 (2006.01) C07D 213/55 (2006.01) C07D 473/08 (2006.01)

Patent

CA 1178970

Abstract of the Disclosure Novel aryloxyalkyl- group containing substances are disclosed which have the ability to reduce the level of cholesterol and triglycerides in the blood. By varying the nature of the aryloxy group, the alkyl group and the moiety attached to the alkyl group, compounds of varying cholesterol-reducing activity can be obtained. The moiety attached to the alkyl group can be a carboxyl group or a substituted carboxyl group, for example a carbamoyl, alkoxycarbonyl, tertiary aminoalkoxy carbonyl or pivaloyloxymethoxy group, in particular, or an olefin- ically unsaturated hydrocarbyl group. Processes for the production of the substances involve coupling phenols with organic halidce which contain the alkyl group and the entire said moiety. Alternatively, a phenol may be reacted with a ketone and a trihalogenated methane derivative to yield a carboxyl gorup-containing substance according to the invention for use as such or as a percursor of a more complex substance according to this invention. Thiophenols may be used to produce thioanalogues of the eforenaid compounds.

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