C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 217/14 (2006.01) A61K 31/135 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) C07D 295/088 (2006.01)
Patent
CA 2238554
Described herein are compounds selective for a 5-HT1D-like receptor, which have the general formula: (see fig. I) wherein R1 is selected from halo and cycloalkyl; R2 is selected from halo and H; R3 is selected from a group of formula III and IV: (see fig. II) (see fig. III) wherein R4 and R5 are independently selected from H, C1-6alkyl and arylalkyl; Y is selected from O and CH2; and m and n are independently 1 or 2. Also described is the use of these compounds as pharmaceuticals to treat indications where stimulation of 5-HT1D-like receptors is implicated, such as migraine.
On décrit ici des composés sélectifs pour un récepteur de type 5-HT1D, qui ont la formule générale (voir fig. I), dans laquelle R1 est choisi parmi un halogène et un cycloalkyle, R2 est choisi parmi un halogène et H, R3 est choisi dans un groupe de formules III et IV (voir fig. fII) (voir fig. III), dans lesquelles R4 et R5 sont choisis indépendamment parmi H, un alkyle C1-6 et un arylalkyle, Y est choisi parmi O et CH2, enfin m et n sont indépendamment 1 ou 2. On décrit également l'emploi de ces composés comme médicaments pour traiter les cas où la stimulation des récepteurs de type 5-HT1D joue un rôle, notamment la migraine.
Glennon Richard A.
Ridout & Maybee Llp
Virginia Commonwealth University
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