Aryloxyarylsulfonylamino hydroxamic acid derivatives

Details Aryloxyarylsulfonylamino hydroxamic acid derivatives Aryloxyarylsulfonylamino hydroxamic acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 311/29 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/35 (2006.01) A61K 31/445 (2006.01) C07D 211/66 (2006.01) C07D 309/14 (2006.01)

Patent

CA 2299355

A compound of formula (I) or the pharmaceutically acceptable salts thereof, wherein R1 is (C1-C6)alkyl; R2 is (C1-C6)alkyl; or R1 and R2 taken together with the carbon atom to which they are attached form a ring selected from (C5-C7)cycloalkyl, 4-tetrahydropyranyl and 4-piperidinyl; R3 is hydrogen or (C1-C6)alkyl; and Y is a substituent of any of the carbon atoms of the phenyl ring capable of supporting an additional bond, preferably from 1 to 2 substituents (more preferably one substituent, most preferably one substituent in the 4-position) on the phenyl ring, independently selected from hydrogen, fluoro, chloro, trifluoromethyl, (C1- C6)alkoxy, trifluoromethoxy, difluoromethoxy and (C1-C6)alkyl.

L'invention porte sur un composé de formule (I), ou ses sels pharmacocompatibles, dans laquelle: R<1> est (C1-C6) alkyle, R<2> est (C1-C6) alkyle, ou R<1> et R<2> pris ensemble avec un atome de carbone auquel ils sont liés forment un cycle sélectionné parmi (C5-C7) cycloalkyle, 4-tétrahydropyranyle et 4-pipéridinyle; R<3> est hydrogène ou (C1-C6) alkyle, et Y est en substituant de l'un des atomes de carbone du cycle phényle capable de porter une liaison additionnelle de préférence de deux substituants (ou mieux, un substituant ou mieux encore un substituant en position 4) sur le cycle phényle, sélectionné indépendamment parmi hydrogène, fluoro, chloro, trifluorométhyle, (C1-C6) alkoxy, trifluorométhoxy, difluorométhoxy, et (C1-C6) alkyle.

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